Effect of andaliman (Zanthoxylum acanthopodium DC.) ethanol extract on doxorubicin-induced toxicity on hematology in male rats

Introduction: Doxorubicin is one of the chemotherapy drugs that have harmful effects on blood hematology. Blood hematological diseases are caused by its adverse and anticancer properties. The antioxidant properties several plants been reported to be closely related reduced toxicity in Andaliman (Zanthoxylum acanthopodium) ethanolic extract (AEE) thought reduce doxorubicin due secondary metabolite content. This study aimed determine effect AEE doxorubicin-induced rats cells. Materials Method: A total 24 male were divided into 6 groups: (1) Normal group; (2) 0.5% Na-CMC (3) 50 mg/kg BW quercetin (4) 75 (5) 150 (6) group 300 administered orally for 9 days. On days 8 9, 10 was administered. Rats sacrificed collection, measured at Integrated Laboratory USU Hospital. Results: reduces parameters. Furthermore, it affects Hb, white cells, platelet monocytes, lymphocytes, neutrophils, protein metabolisms as well organ damage. Dose or all toxins near-normal levels decrease lymphocyte neutrophil suppressive activity doxorubicin. Conclusion: ethanol can improve Hb count, metabolism, used combination with toxicity.
 Keywords: toxicity, hematology, doxorubicin, andaliman, Zanthoxylum acanthopodium,